. 2013 Apr 17;20(1):23. doi: 10.1186/1423-0127-20-23

Table 1.

Role of plasmalemmal Ca²⁺channels in cell migration and tumor metastasis

Ca²⁺channel	Cell type	Mechanisms and effectors	References
*Store-dependent SOC channels*
STIM1-Orai1	• Human cervical cancer SiHa and CaSki cells	• Increase in EGF-stimulated cellular migration and invasion	[29,30]
		• Increase in focal adhesion dynamics through the Ca²⁺-regulated protease calpain and cytoplasmic kinase Pyk2
		• Upregulation of EGF-induced MLC phosphorylation and actomyosin reorganization
		• Upregulation of VEGF production
		• Promotion of tumor growth and angiogenesis in a xenograft mice model
	• Human breast cancer MDA-MB-231 cells and mouse mammary tumor 4 T1 cells	• Increase in serum-induced cellular migration and invasion	[31]
		• Increase in focal adhesion turnover rates through Ras and Rac1
		• Promotion of tumor growth and metastasis in a xenograft mice model
STIM-Orai3	• Human breast cancer MCF7 cells (ER⁺ breast cancer cells)	• Increase in anchorage-independent growth and Matrigel invasion	[32,33]
		• Increase in tumorigenesis in a xenograft mice model
*Store-independent SOC channel*
SPCA2-Orai1	• Human breast cancer MCF-7 cells	• Constitutively active store-independent Ca²⁺ influx	[34]
SPCA2-Orai1	• Human breast cancer MCF-7 cells	• Promotion of proliferation and colony formation	[34]
		• Increase in tumorigenesis in a xenograft mice model
*TRP channels*
TRPM1	• Murine melanoma B16-F1 cells	• Reduce in tumor metastasis	[35,36]
TRPM7	• Human breast cancer MDA-MB-231 cells and MEF cells	• Increase in cellular migration	[18,37-39]
		• Guidance of polarized cellular migration
		• Increase in peripheral focal adhesion turnovers through the Ca²⁺-regulated protease m-calpain
		• Inhibition of myosin II-based cell contractility
		• Increase in tumorigenesis in a xenograft mice model
	• Human nasopharyngeal cancer 5-8 F and 6-10B cells	• Increase in cellular migration	[40]
	• Human lung cancer A549 cells	• Increase in EGF-stimulated cellular migration	[38]
TRPM8	• Human prostate cancer PC-3 cells	• Decrease in cellular migration	[41,42]
TRPM8	• Human prostate cancer PC-3 cells	• Inactivation of FAK	[41,42]
TRPV1	• Human hepatoblastoma HepG2 cells	• Increase in HGF-stimulated cellular migration	[43,44]
TRPV2	• Human prostate cancer LNCaP and PC-3 cells	• Increase in cellular migration and invasion	[45]
		• Induction of invasive enzymes MMP-2, MMP-9 and cathepsin B
		• Increase in tumorigenesis in a xenograft mice model
TRPC6	• Human glioblastoma cells	• Increase in cell proliferation through regulation of CDK1 activation and Cdc25C expression	[46,47]
		• Increase in anchorage-independent growth and Matrigel invasion
		• Increase in endothelial cell tube formation
		• Increase in tumorigenesis in a xenograft mice model

Cdc25C, cell division cycle 25 homolog C; CDK1, cyclin-dependent kinase 1; EGF, epidermal growth factor; ER, estrogen receptor; FAK, focal adhesion kincase; HGF, hepatocyte growth factor; SPCA2, secretory pathway Ca²⁺-ATPase; MEF, mouse embryonic fibroblast; MMP, matrix metalloproteinase; Pyk2, proline-rich tyrosine kinase 2; VEGF, vascular endothelial cell growth factor.