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. 2013 Apr 29;8(4):e62125. doi: 10.1371/journal.pone.0062125

Figure 4. SMC10 cells have altered growth patterns and abnormal cell morphologies.

Figure 4

A) Growth pattern and size differences between the parental 293/EcR and stable mutant clone 10 cell lines. B) Comparisons of the growth morphologies of the 293/EcR and SMC10 cells. a) 293/EcR cells undergoing cell division. b) 293/EcR cells prior to cytokinesis. c and d) SMC10 cells remain attached in dumbbell like structures. C) Cell cycle analyses of the uninduced and Ponasterone A treated C13 and SMC10 cell lines. In the SMC10 cells the number of cells in the G2/M phase has increased compared to the control 293/EcR cell lines. p<0.05. D) Comparison of the G2/M and sub G1 phases of C13 and SMC10 cell lines. The SMC10 cells are stalled at the G2/M phase. p<0.05.