Table 4. Main finding from Cochrane review and this update for complete cure.
| Intervention | Comparator | Effect measure (RR, OR, mean) [95%confidence interval] [Heterogeneity] | Follow up period | Parasite species | References |
| Miltefosine | Meglumineantimoniate | ITT RR 1.12 (0.85–1.47); N = 584; I2 78% | 6 months | L. braziliensis, L. panamensis and L. guyanensis | Chrusciak,2011 [73];Machado,2010 [74];Rubiano,2012 [70];Velez,2010 [75] |
| Miltefosine* | Meglumineantimoniate | ITT RR 1.22 (1.02–1.46); N = 206; I2 0% | 6 months | L. panamensis and L. guyanensis | Chrusciak,2011 [73];Rubiano,2012 [70] |
| Miltefosine | Meglumineantimoniate* | ITT; RR 0.81 (0.69–0.97) | 6 months | L. braziliensis, L panamensis | Velez,2010 [75] |
| Imiquimod* | Placebo | ITT RR 1.45 (1.12–1.88); N = 134; I2 0%; | 3 months | L. peruviana, L. guyanensis, L. braziliensis | Miranda V 2005 [52];MirandaV 2009 [76]Arevalo 2007 [35] |
| Imiquimod | Placebo | ITT RR 1.09 (0.73–1.62); N = 120; I2 58% | 1 year | L. peruviana, L. guyanensis, L. braziliensis | Miranda V 2005 [52];MirandaV 2009 [76] |
| Pentamidineisethionate | Meglumineantimoniate | ITT Yes; 6 of 80 (7.5%); N = 70 | 6 months | Leishmania braziliensis | Andersen,2005 [32] |
| Meglumineantimoniate | Meglumineantimoniate | ITT = No; 4 of 43 (9.3%); N = 43 | 2 years | No information | Figueiredo,1991 [42] |
| Sodiumstibogluconate | Sodiumstibogluconate | ITT = No; 5 of 40 (12.5%); N = 40 | 1 year | L. braziliensis | Franke,1994 [43] |
| Thermotherapy | Meglumineantimoniate | ITT = No; 1 of 37 (2.7%); N = 37 | Treatmentend | L. braziliensis | Lobo,2006 [47] |
| Oralpentoxyfilline+Sodiumstibogluconate | Placebo+Sodiumstibogluconate | ITTI = Yes uninformed; N = 23 | 4 months | L. braziliensis | Machado,2007 [48] |
| Meglumineantimoniate | Thermotherapy | ITT = Yes, uninformed; N = 66 | 2 months | L. braziliensis andL. mexicana | Navin1990 [53] |
| Oral Ketoconazole | Sodiumstibogkuconate | ITT = No; 7 of 120 (5.83%); N = 120 | 2 months | L. braziliensis andL. mexicana | Navin1992 [54] |
| Meglumineantimoniate | Meglumineantimoniate | ITT = Yes; uninformed; N = 23 | 2 months | L. braziliensis | Oliveira-Neto,1997 [56] |
| Sodiumstibogluconate | Sodiunstibogluconate | ITT = Yes, uninformed; | Treatmentend | L. braziliensis (27) L. mexicana (9) L. chagasi (3) | Oster,1995 [57] |
*
Significant difference favoring this intervention.