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. 2013 Apr 29;8(4):e59998. doi: 10.1371/journal.pone.0059998

Figure 1. Silexan reduces anxiety-related behaviour in the elevated plus maze and increases pentobarbital-induced sleeping time.

Figure 1

(A–C) Mice were treated orally with diazepam (2.5 mg/kg BW), pregabalin (100 mg/kg BW) or Silexan (1–30 mg/kg BW) for three days. Diazepam, pregabalin and Silexan increased the time spent in the open arm (A, B) and entry number (C). (D) Mice were treated orally with pregabalin (100 mg/kg BW) or Silexan (1–30 mg/kg BW) for nine days. Sleeping time was determined after i.p. application of pentobarbital (45 mg/kg BW). All data presented are mean values ± SEM using 8 mice per treatment group (unpaired t-test).