. Author manuscript; available in PMC: 2013 Apr 29.

Published in final edited form as: Diabetologia. 2012 Jun 17;55(9):2394–2401. doi: 10.1007/s00125-012-2608-z

Table 2.

Stepwise linear regression of factors associated with type 1 diabetes age at onset 1801 sib pairs

Risk Factor	Coeff.	SE	p Value
Proband (yes=1, no=0)	−1.9909	0.2372	6.6E-17
DR-DQ (DR3/4=4, DR3/3=3, DR4/4=2, DR4/x or DR3/x=1, DRx/x=0)	−0.7125	0.0801	9.0E-19
A*24:02 (0, 1 or 2 copies carried)	−1.5917	0.2804	1.5E-08
B*39:06 (0, 1 or 2 copies carried)	−2.6639	0.5084	1.7E-07
B*44:03 (0, 1 or 2 copies carried)	1.0109	0.5996	0.0919
B*18:01 (0, 1 or 2 copies carried)	−0.4958	0.2904	0.0878
Gender (female=2 male=1)	−0.5685	0.1189	1.8E-06

R² accounted for by HLA genotype	0.03843

results are adjusted for cohort of origin. Coefficients for the categorical variable “cohort” are not shown.

^##

DR3= DRB1*03:01 DQB1*02:01 DR4= DRB1*04:01/02/04/05/08 DQB1*02:01 or 03:02 or 03:04 x = any other DRB1-DQB1 haplotypes, DRx/x is also any genotype that carried DQB1*0602, DRB1*14:O1 DQB1*05:03 or DRB1*07:01 DQB1*03:03.