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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Dec 5;1832(7):1028–1040. doi: 10.1016/j.bbadis.2012.11.021

Figure 2. Asbestos-induced pulmonary fibrosis is blocked in Rac-1 null mice.

Figure 2

Wild-type (WT) and Rac1 null mice were intratracheally exposed to chrysotile asbestos (100 µg). Micro-CT scan images were obtained on live mice (in vivo) 21 days after exposure. Images are representative of three WT (A) and three Rac1 null (B) mice. Twenty one days after exposure, the mice were euthanized and the lungs were removed and processed for collagen deposition using Masson's trichrome staining. Micrographs are representative of 10 WT (C) and 10 Rac1 null (D) mice. (E), mice were euthanized 21 days after exposure, and lungs were removed and homogenized for hydroxyproline assay. WT (n = 4) and Rac1 null (n = 4); *p < 0.0208. Experimental data from Osborn-Heaford et.al (reference 16) was used with permission.

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