Table 3.
Top bio functions associated with high-fat diet responsive genes identified in long-term high-fat diet-fed C57BL/6 J mice
| Top bio functions | ||
|---|---|---|
| p value | # Genes | |
| Diseases and disorders | ||
| Inflammatory response | 2.35E−14–2.00E−02 | 71 |
| Immunological disease | 7.65E−14–1.61E−02 | 40 |
| Connective tissue disorders | 2.88E−11–2.20E−03 | 33 |
| Inflammatory disease | 5.11E−11–2.00E−02 | 39 |
| Skeletal and muscular disorders | 5.11E−11–7.21E−03 | 35 |
| p value | # Genes | |
|---|---|---|
| Molecular and cellular functions | ||
| Antigen presentation | 2.35E−14–2.00E−02 | 40 |
| Cell-to-cell signaling and interaction | 2.35E−13–2.00E−02 | 57 |
| Cellular movement | 3.52E−10–2.00E−02 | 45 |
| Cellular function and maintenance | 3.52E−09–1.75E−02 | 36 |
| Lipid metabolism | 2.06E−06–2.00E−02 | 54 |
| p value | # Genes | |
|---|---|---|
| Physiological system development and function | ||
| Hematological system development and function | 2.35E−13–2.00E−02 | 68 |
| Immune cell trafficking | 2.35E−13–2.00E−02 | 48 |
| Tissue development | 1.45E−10–2.00E−02 | 36 |
| Hematopoiesis | 1.94E−05–1.97E−02 | 36 |
| Cell-mediated immune response | 2.98E−05–2.00E−02 | 28 |
| Top tox lists | ||
|---|---|---|
| p value | Ratio | |
| Top tox functions | ||
| Xenobiotic metabolism signaling | 7.25E−09 | 14/97 (0.144) |
| Fatty acid metabolism | 1.71E−05 | 11/118 (0.093) |
| Cytochrome P450 panel | 1.94E−05 | 6/31 (0.194) |
| Positive acute phase response proteins | 1.94E−05 | 6/30 (0.2) |
| LPS/IL-1-mediated inhibition of RXR function | 3.24E−05 | 13/176 (0.074) |
| p value | # Genes | |
|---|---|---|
| Hepatotoxicity | ||
| Liver steatosis | 1.08E−02–1.32E−01 | 7 |
| Hepatocellular carcinoma | 2.15E−03–2.15E−03 | 5 |
| Liver hepatitis | 2.15E−03–1.32E−01 | 5 |
| Liver damage | 3.46E−03–5.88E−02 | 8 |
| Liver steatohepatitis | 3.82E−03–1.32E−01 | 2 |