Table 1.

Gene ontology enrichment analysis of transcripts correlated to TGR5 expression in adipose tissue in the Sib Pair study.

GO term	Category	Counta	Adj p-valueb
Transcripts negatively correlated to TGR5 expression
Mitochondrion	CC	160	3.0E−20
Mitochondrial part	CC	100	8.2E−16
Intracellular organelle lumen	CC	203	4.4E−13
Organelle lumen	CC	205	7.5E−13
Membrane-enclosed lumen	CC	208	9.0E−13
Translation	BP	67	1.6E−11
Ribosome	CC	46	7.1E−11
Mitochondrial envelope	CC	68	6.1E−10
Organelle inner membrane	CC	58	6.3E−10
Mitochondrial membrane	CC	64	1.9E−09
Mitochondrial lumen	CC	46	2.2E−09
Mitochondrial matrix	CC	46	2.2E−09
Ribosomal subunit	CC	32	3.5E−09
Ribonucleoprotein complex	CC	75	4.8E−09
Mitochondrial inner membrane	CC	53	6.1E−09
Transcripts positively correlated to TGR5 expression
Endoplasmic reticulum	CC	135	5.7E−08
Actin binding	MF	54	0.000023
Cytoskeletal protein binding	MF	74	0.000031
GOLGI apparatus	CC	115	0.000033
Lysosome	CC	41	0.00006
Lytic vacuole	CC	41	0.00006
Endoplasmic reticulum part	CC	54	0.00067
Endoplasmic reticulum lumen	CC	21	0.00078
Vacuole	CC	42	0.0014
Actin cytoskeleton organization	BP	39	0.0019
Cortical cytoskeleton	CC	15	0.0019
Actin filament-based process	BP	41	0.0023
Cell cortex	CC	28	0.0023
Proteinaceous extracellular matrix	CC	48	0.0023
Extracellular matrix part	CC	24	0.0027

CC = cellular component; BP = biological process; MF = molecular function.

^aNumber of correlated transcripts included in the specific GO term.

^bThe table displays the top 15 enriched GO terms based on the adjusted p-value (Benjamini).