Table 1.

Effects of exposure to arsenite for 30 min on endothelium-dependent relaxations to CPA and ACh in the iliac artery.

CPA	n	pIC50	Rmax, %
Control	9	4.99 ± 0.07	94.4 ± 2.8
Arsenite 100 μM		4.98 ± 0.10	91.6 ± 3.3
L-NAME + indo	6	4.76 ± 0.07	82.7 ± 3.9
L-NAME + indo + arsenite 30 μM		4.85 ± 0.05	79.8 ± 3.3
L-NAME + indo	22	4.85 ± 0.05	82.1 ± 1.8
L-NAME + indo + arsenite 100 μM		5.16 ± 0.08***	83.1 ± 1.7

ACh	n	pEC50	Rmax, %
Control	12	7.32 ± 0.10	91.3 ± 2.2
Arsenite 100 μM		7.52 ± 0.10	91.1 ± 2.3
L-NAME + indo	12	6.83 ± 0.09	72.7 ± 4.1
L-NAME + indo + arsenite 100 μM		7.08 ± 0.09***	72.4 ± 4.0

Experiments were performed in the absence (control) and presence of L-NAME (300 μM) and indomethacin (10 μM). Potency (negative log IC₅₀ or log EC₅₀) and maximal responses (R_max) are given as mean ± SEM. n denotes the number of animals studied.

^***P < 0.001 compared with time-matched preparations not exposed to arsenite.