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. 2013 Apr 29;201(3):439–448. doi: 10.1083/jcb.201209023

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© 2013 Upadhyay et al.

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Figure 6. — A potential model for Sanpodo trafficking in SOP lineage cells. Sanpodo expression is induced in SOP cells and the bulk of Sanpodo (red) enters the endocytic system, along with Notch, from the basolateral membrane via an interaction of Numb (green) and the Sanpodo NPAF motif. An alternative route for Sanpodo and Notch endocytosis requires the ELL motif. Endocytosed Sanpodo is directed to the lysosome and shunted away from the recycling to the apical membrane by the ELL motif. Sanpodo targeting to the apical membrane is regulated by the exocyst complex and the AP-1 complex of endocytic adaptor proteins.