Skip to main content
. 2013 Apr 30;3:1754. doi: 10.1038/srep01754

Figure 7. Reduced BATF, c-maf and IL-21 expression after in vitro treatment with α-IL-6R antibody.

Figure 7

(a) In vitro treatment with OVA (500 μg/ml) and additionally anti-IL-6 R antibody or IgG (15 μg/ml). (b,c) Reduced expression of Batf (b), but not Rorγt (c) after treatment with α-IL-6R antibody.(d) c-maf mRNA expression in total lung cells from untreated, OVA-treated and/or α-IL-6R antibody treated wild-type and T-bet(−/−) mice (n = 3–5 mice per goup). (e) Decreased Il-21 mRNA expression in lung CD4+ T cells isolated from wild-type and T-bet(−/−) mice after α-IL-6R antibody treatment. Cells were cultured for 24 h with α-CD3 and α-CD28 (n = 10–16 mice per group). Data are mean ± s.e.m. Students t test was used to calculate statistical significances. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001.