Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 May;141(5):619–632. doi: 10.1085/jgp.201210820

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Jensen et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — K_V1.2/2.1 permeation mechanism. (A and B) Position of the incoming ion versus the centroid of the two SF-bound ions above it (left panels) and position of the leaving ion versus the centroid of the two SF-bound ions below it (right panels) at low (A) and high (B) voltages. The color bar is in units of log(ρ[x,y]); ρ[x,y] is the two-dimensional histogram of ion positions averaged over either low- or high-voltage simulations. The minima represent the four predominant three-ion configurations in the knock-on permeation mechanism; the mechanism is indicated in A (right), with S0–S6 denoting SF ion-binding sites (see Fig. S1). The knock-on intermediate is S5[S4,S2]; its formation is the rate-limiting step in the indicated mechanism (Jensen et al., 2010). (C) Low-voltage data similar to those in A, but obtained with weakened K⁺–carbonyl oxygen interactions (Roux and Bernèche, 2002; Allen et al., 2006b). The predominant permeation mechanism, in which the knock-on intermediate is not formed, is shown in the right panel.