Table 1.
Anion permeability ratios relative to PCl of mock-, mTMEM16F-, I342A-, K616E-, and R636E-transfected HEK293 cells
| Px/PCl | Mock | TMEM16F | I342A | K616E | R636E |
| PSCN/PCl | 4.20 ± 1.03 (NS) | 3.46 ± 0.80 | 2.62 ± 0.38 (NS) | 2.19 ± 0.23 (NS) | 1.64 ± 0.37a |
| PI/PCl | 1.47 ± 0.16 (NS) | 1.82 ± 0.20 | 1.85 ± 0.22 (NS) | 1.35 ± 0.11a | 0.86 ± 0.09a |
| PBr/PCl | 0.96 ± 0.11a | 1.32 ± 0.06 | 1.32 ± 0.21 (NS) | 1.09 ± 0.08 (NS) | 0.86 ± 0.11a |
| PAsp/PCl | 0.57 ± 0.08 (NS) | 0.51 ± 0.06 | 0.53 ± 0.11 (NS) | 0.70 ± 0.06 (NS) | 0.50 ± 0.06 (NS) |
The ratios were calculated by Eq. 2.
a
Significant differences between relative anion permeabilities of mTMEM16F-WT and mock or mutant mTMEM16F-expressing cells are indicated (P < 0.05), when tested with one-way ANOVA and using a Student-Newman-Keuls post hoc test.