Fig 1.

C. albicans proteins similar to S. cerevisiae and S. pombe SR-like proteins. In domain comparison of two SR-like proteins in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Candida albicans, RNA recognition motifs (RRM) and arginine-rich (R-rich) domains, as well as nonconserved N- and C-terminal domains, are shown. Asterisks indicate locations of SR/RS dipeptides. The second domain of the C. albicans Npl3-like protein (RRM′) has sequence similarity with the other two atypical RRMs in ScNpl3 and SpSrp2 but is not recognized as an RRM by protein signature recognition searches (InterProScan). GenBank accession numbers for these proteins are as follows: NP_010720.1 (ScNpl3), XP_715038.1 (CaNpl3), NP_594570.1 (SpSrp2), CAA22007.1 (CaSlr1), and NP_596398.1 (SpSrp1).