Fig 5.

Deletion of SLR1 decreases cell damage by C. albicans in vitro. FaDu oral epithelial cells (A) or human umbilical vein endothelial cells (B) were preloaded with ⁵¹Cr and incubated for 3 h at 37°C with the following C. albicans strains: the wild type (WT1, DAY185; WT2, AMC81), the npl3Δ/Δ mutant (AMC18), the npl3Δ/Δ+NPL3 strain (AMC22), the slr1Δ/Δ mutant (AMC82), the slr1Δ/Δ+SLR1 strain (AMC104), the npl3Δ/Δslr1Δ/Δ mutant (AMC83), the npl3Δ/Δ slr1Δ/Δ+SLR1 strain (AMC111), and the npl3Δ/Δ+NPL3 slr1Δ/Δ strain (AMC113). Results are the means ± SD of data from 3 experiments, each performed in triplicate. *, P < 0.01 compared to results for the wild type.