Fig 2.

DMPA treatment results in enhanced body weight increases. Mice (n = 10 mice/group) from both the C57BL/6 (A) and BALB/c (B) strains received weekly intramuscular injections of 1 mg DMPA, and the control mice received an equal volume of saline (50 μl). DMPA injections commenced 1 week before (week −1) aerosol infection with M. tuberculosis H37Rv (week 0). Differences in body weight among the four groups were determined in two independent experiments by one-way analysis of variance (ANOVA) with the Bonferroni post hoc test at each of the time points, and the data are represented as means ± SEM. From 1 week postinfection, DMPA-treated mice (DMPA and DMPA-M. tuberculosis groups) gained significantly more weight than the untreated (naïve and M. tuberculosis) groups (0.001 < P < 0.05). No differences were found between naïve and M. tuberculosis-infected mice and between the two DMPA-treated groups. Each graph is a representative of the two independent experiments.