Fig 2.

Release of uric acid into supernatant medium of cultured T84 cells in response to EPEC infection. (A) Comparison of uric acid release between commensal E. coli strain HS, wild-type EPEC strain E2348/69, and the plasmid-cured derivative of E2348/69, JPN15. *, significantly greater than JPN15. (B) Effect of increasing multiplicity of infection (MOI) on uric acid released from cultured T84 monolayers by infection with Salmonella enterica serotype Enteritidis, EPEC JCP88, and E. coli HS. (C) Effect of the xanthine oxidase inhibitors allopurinol and oxypurinol on EPEC-induced uric acid release from T84 cells. *, significantly increased compared to the uninfected control; **, significantly decreased compared to JCP88 without allopurinol. uninf, uninfected.