Fig 1.

(A) Survival of Tg and non-Tg mice infected with Cryptococcus neoformans (strain H99 or C23) or Cryptococcus gattii (strain R265 or R272). Ten mice were infected intranasally at each of the indicated inocula. Significant differences are indicated as follows: *, P < 0.01 versus mice infected with the same strain at an inoculum of 1.25 × 10⁶ CFU; and **, P < 0.01 for Tg versus non-Tg mice infected with identical inocula of the same strain. (B and C) Lungs harvested at necropsy from Tg and non-Tg mice infected with C. neoformans H99 or C. gattii R265 all showed multiple hemorrhagic (filled arrowhead) and abscess-like (open arrowhead) surface lesions. Representative examples are shown for a non-Tg mouse infected with C. neoformans H99 (B) and a Tg mouse infected with C. gattii R265 (C).