Fig 2.
Increased survival and control of fungal growth in 5-LO−/− mice during experimental PCM. (A) B6.129 and 5-LO−/− mice were infected (i.v.) with 106 P. brasiliensis (Pb18) yeast cells, and the number of CFU was determined (n = 3 to 5 mice/group) in the lungs, liver, and spleen at days 7, 15, 30, 60, and 90 p.i. The data represent the means ± the SEM. *, P < 0.05 compared to B6.129 mice. nd, not detected. Similar results were obtained in three independent experiments. (B) The survival rate was assessed for a period of 110 days p.i. (n = 30 mice/group).