Table 2.
Quantitative response to 10 s stimulation with 20 mM K+. The results were subcategorized according to whether they responded to the capsaicin protocol the respective neuron was stimulated with. Results are shown as median (5%–95% percentile).
| Animal | Capsaicin response | n | AUC0–180 s | Δ | %-Δ |
|---|---|---|---|---|---|
| Control | Y | 157 | 34.68 (3.05–138.27) | 1.05 (0.27–1.65) | 175.36 (39.50–290.96) |
| N | 392 | 28.02 (3.02–93.19) # | 0.88 (0.25–1.30) # | 149.64 (42.24–233.10) # | |
| Diabetic | Y | 193 | 42.97 (5.08–155.09) | 1.25 (0.38–1.96)* | 202.78 (60.60–353.75)* |
| N | 385 | 40.99 (3.45–105.17) ∗$ | 1.01 (0.28–1.59) ∗# | 170.37 (21.97–288.22) ∗# |
AUC: Area under the curve for 0–180 s, Δ: the absolute change in [Ca2+]i (fluorescence ratio), %-Δ: the change in [Ca2+]i (fluorescence ratio) measured in % change from baseline. Y: Yes and N: No. *P < 0.001 versus corresponding control neurons, # P < 0.001 and $ P < 0.05 versus corresponding capsaicin-responsive neurons.