Figure 3.

Slug sensitized lung cancer cells to tubulin-binding agents (TBAs) including vinorelbine, vincristine, and paclitaxel. (A) Growth inhibition by anticancer agents (vinorelbine, vincristine, paclitaxel, AG1478, and cisplatin) was evaluated using an MTT assay against A549/EGFP and A549/Slug cells. The data shown represent the average ± SD of three independent experiments. (B) Growth inhibition by vinorelbine was also confirmed in other stable transfectants: Ma1/EGFP, Ma1/Slug, H1299/EGFP, and H1299/Slug cells. The data shown represent the average ± SD of three independent experiments. VNR, vinorelbine; VCR, vincristine; PTX, paclitaxel. AG1478: an EGFR tyrosine kinase inhibitor, CDDP, cisplatin; EGFP, enhanced green fluorescent protein; SD, standard deviation.