Table 1.
Virus, clinical signs, virus replication, and seroconversion of tree shrews
|
Virus |
Body weight (g)a |
Body temperature (°C)b |
Nasopharyngeal secretion |
Peak mean nasal wash titer±SD (day)d |
Number positive/total (average logTCID50/mL)e |
Seroconversion(HI titer)f |
||
|---|---|---|---|---|---|---|---|---|
| Nasal mucosa | Tracheal | Lung | ||||||
| A/PR8/34 |
99.77±0.42 |
39.78±0.44 |
Positive (3/3)c |
2.94±0.92 (2) |
(3/3) (1.89) |
(0/3) |
(0/3) |
(3/3) 80,80,320 |
| GZ/02/09 |
98.92±0.63 |
40.26±0.55 |
Positive (3/3) |
3.00±0.33 (2) |
(3/3) (1.90) |
(0/3) |
(0/3) |
(3/3) 80,160,640 |
| S-OIV/GZ/07/09 |
100.24±0.49 |
40.57±0.59 |
Positive (3/3) |
4.24±0.25 (1) |
(3/3) (2.17) |
(0/3) |
(0/3) |
(3/3) 80,160,640 |
| Control | 99.46±0.36 | 38.20±0.47 | No | 0 | (0/3) | (0/3) | (0/3) | (0/3) 0,0,0 |
a Bodyweight on day o.
b Average body temperature on day 2 p.i.
c Number of inoculated tree shrews/total number.
d Peak nasal wash titers are expressed as the mean±SD log10 TCID50/mL.
e Virus titers in different tissues was detected on day 2 p.i.
f Serum was collected on day 14 p.i., and homologous strains were used with chicken RBCs in HI assay.