Table 3.
Common functional classes unifying genes up- and downregulated during myogenic differentiation
| Common functional classes | Unique genes/cluster | UP/DOWN | % miRNA targets | P-value | FDR | ||
|---|---|---|---|---|---|---|---|
|
1 |
Protein modification/assembly |
|
|
|
|
|
|
| |
ubiquitination/proteolysis |
305 |
UP |
16,07 |
4,118E-23 |
7,67E-20 |
10_up |
| |
162 |
DOWN |
39,51 |
2,97E-05 |
0,055652 |
19_down |
|
| |
protein complex assembly |
131 |
UP |
9,16 |
0,0001135 |
0,21125 |
11_up |
| |
177 |
DOWN |
30,51 |
7,01E-17 |
2,11E-13 |
20_down |
|
|
2 |
Transport/localization |
|
|
|
|
|
|
| |
transport/localization |
243 |
UP |
16,05 |
1,299E-17 |
2,42E-14 |
12_up |
| |
279 |
DOWN |
41,22 |
1,27E-11 |
2,39E-08 |
21_down |
|
|
3 |
Transcription |
|
|
|
|
|
|
| |
transcription regulation |
458 |
UP |
13,32 |
7,64E-10 |
1,42E-06 |
13_up |
| |
36 |
DOWN |
41,67 |
0,000311 |
0,57965 |
22_down |
|
| |
transcription (-) reg, |
148 |
UP |
11,49 |
9,994E-07 |
0,001862 |
14_up |
| |
203 |
DOWN |
36,45 |
1,19E-09 |
2,23E-06 |
23_down |
|
| |
chromatin organization/modification |
86 |
UP |
9,30 |
0,0005777 |
1,070598 |
15_up |
| |
153 |
DOWN |
30,72 |
5,88E-23 |
1,1E-19 |
24_down |
|
|
4 |
Apoptosis |
|
|
|
|
|
|
| |
apoptosis |
216 |
UP |
17,59 |
8,615E-07 |
0,001605 |
16_up |
| |
216 |
DOWN |
38,43 |
1,26E-08 |
2,36E-05 |
25_down |
|
|
5 |
Signaling |
|
|
|
|
|
|
| |
reg, of kinase activity |
204 |
UP |
15,69 |
1,362E-06 |
0,002537 |
17_up |
| |
233 |
DOWN |
40,77 |
2,22E-06 |
0,00416 |
26_down |
|
|
6 |
Cell morphogenesis |
|
|
|
|
|
|
| |
cytoskeleton organization |
130 |
UP |
14,62 |
0,0002361 |
0,438978 |
18, 19_up |
| 193 | DOWN | 35,23 | 1,05E-17 | 1,96E-14 | 27_down |
Subclasses are italicized, the cutoff value for differentially expressed genes was set to 1.2 fold change.