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. 2013 Apr 30;8(4):e63205. doi: 10.1371/journal.pone.0063205

Figure 5. Expressions of the histone deacetylase, Hdac1 and the transcriptional co-activator, P300 were modified in P30 T17M RHO CHOP−/− retinas (N = 3).

Figure 5

A: A 78% reduction in the P300 protein level was observed in the T17M RHO CHOP−/− retina compared to T17M RHO. The normalized level of P300 was 0.3±0.06 a.u. in T17M RHO vs. 0.1±0.02 a.u. in T17M RHO CHOP−/− (P = 0.02). B: A 245% increase in Hdac1 protein expression was observed in T17M RHO CHOP−/− retinas (0.22±0.05 arbitrary units in T17M RHO vs. 0.54±0.08 a. u. in T17M RHO CHOP−/−, P = 0.03). Bottom: Representative images of western blots treated with antibodies against P300, HDAC1 and β-actin proteins.