Table 4. Excess cumulative incidence function at 5 y post bleed by age group, adjusted for lifestyle factors and co-morbidity.
| Causes of Death | Age Range | Adjusted for Gender onlya | Adjusted for Alcohol, Smoking, and Gender | Adjusted for Co-morbidity, Alcohol, Smoking, and Gender | |||
| eCIF | (95% CI) | eCIF | (95% CI) | eCIF | (95% CI) | ||
| Upper GI neoplasms | ≤50 y | 0.61 | (0.33–0.89) | 0.63 | (0.33–0.92) | 0.62 | (0.34–0.90) |
| 50–59 y | 3.62 | (2.02–5.22) | 3.79 | (2.55–5.03) | 3.52 | (2.30–4.74) | |
| 60–69 y | 6.58 | (4.28–8.89) | 6.67 | (4.88–8.46) | 6.00 | (4.08–7.92) | |
| 70–79 y | 5.65 | (3.70–7.59) | 5.63 | (4.21–7.05) | 5.05 | (3.51–6.58) | |
| ≥80 y | 4.41 | (2.79–6.03) | 4.39 | (3.07–5.71) | 4.08 | (2.65–5.50) | |
| Other neoplasms (not upper GI) | ≤50 y | 1.29 | (0.86–1.72) | 1.26 | (0.78–1.75) | 1.17 | (0.74–1.60) |
| 50–59 y | 4.17 | (3.17–5.18) | 4.05 | (2.67–5.42) | 3.20 | (2.06–4.33) | |
| 60–69 y | 6.64 | (5.22–8.06) | 6.39 | (4.38–8.39) | 4.67 | (2.94–6.40) | |
| 70–79 y | 5.23 | (3.87–6.59) | 5.11 | (3.39–6.82) | 3.64 | (2.22–5.06) | |
| ≥80 y | 4.38 | (2.65–6.12) | 4.34 | (2.4–6.28) | 3.19 | (1.62–4.76) | |
| Cardiovascular | ≤50 y | 0.62 | (0.32–0.92) | 0.65 | (0.32–0.97) | 0.50 | (0.25–0.74) |
| 50–59 y | 2.36 | (1.53–3.19) | 2.21 | (1.29–3.14) | 1.49 | (0.82–2.15) | |
| 60–69 y | 4.66 | (3.52–5.80) | 4.50 | (2.95–6.04) | 2.89 | (1.75–4.02) | |
| 70–79 y | 6.44 | (4.76–8.12) | 6.32 | (4.05–8.59) | 4.02 | (2.34–5.70) | |
| ≥80 y | 7.64 | (3.97–11.30) | 7.66 | (3.41–11.91) | 5.32 | (2.16–8.48) | |
| Respiratory b | ≤50 y | 0.31 | — | 0.26 | — | 0.20 | — |
| 50–59 y | 1.04 | — | 0.99 | — | 0.69 | — | |
| 60–69 y | 2.08 | — | 1.92 | — | 1.28 | — | |
| 70–79 y | 3.24 | — | 3.15 | — | 2.08 | — | |
| ≥80 y | 4.56 | — | 4.51 | — | 3.21 | — | |
| Digestive | ≤50 y | 3.04 | (2.06–4.02) | 2.38 | (1.7–3.05) | 2.36 | (1.75–2.97) |
| 50–59 y | 5.33 | (3.45–7.22) | 4.20 | (2.98–5.42) | 4.05 | (2.82–5.27) | |
| 60–69 y | 3.90 | (2.17–5.63) | 3.53 | (2.51–4.55) | 3.36 | (2.25–4.47) | |
| 70–79 y | 4.45 | (2.46–6.43) | 4.09 | (3.13–5.06) | 3.88 | (2.74–5.02) | |
| ≥80 y | 8.56 | (4.58–12.54) | 8.23 | (6.33–10.13) | 8.01 | (5.82–10.20) | |
| Other | ≤50 y | 1.65 | (1.10–2.19) | 1.55 | (0.95–2.14) | 1.39 | (0.89–1.89) |
| 50–59 y | 3.09 | (2.17–4.02) | 3.11 | (2.01–4.21) | 2.65 | (1.68–3.64) | |
| 60–69 y | 2.37 | (1.63–3.11) | 2.46 | (1.51–3.41) | 2.06 | (1.16–2.96) | |
| 70–79 y | 3.06 | (2.15–3.97) | 3.29 | (2.09–4.48) | 2.78 | (1.64–3.93) | |
| ≥80 y | 2.54 | (0.58–4.50) | 2.73 | (0.45–5.01) | 2.72 | (0.42–5.02) | |
95% CIs obtained by bootstrapping (500 iterations).
a
As in Table 3.
b
CIs were too unstable to be interpretable for respiratory causes of death due to small numbers.
eCIF, excess CIF; the absolute difference in the CIF between patients with non-variceal bleeding and age, sex, year, and general practice matched controls without non-variceal bleeding; GI, gastrointestinal.