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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Trends Cardiovasc Med. 2012 Apr;22(3):72–76. doi: 10.1016/j.tcm.2012.06.015

Figure 3. Our working model.

Figure 3

Illustration of our working model showing that physical interaction between adjacent CaV1.2 via LZ motifs on their C-termini permits coordinated gating of clusters of CaV1.2 channels, leading to amplification of Ca2+ influx. We propose that AKAP79/150 stabilizes the interaction via a partial LZ motif on its C-terminus.