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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Nature. 2009 Dec 9;463(7277):49–53. doi: 10.1038/nature08637

Figure 1. Extinction during reconsolidation prevents spontaneous recovery of extinguished fear.

Figure 1

(a) Experimental design and timeline. (b) Mean differential SCRs (CS+ minus CS−) during acquisition (late phase), extinction (last trial) and re-extinction (first trial) for each experimental group (10 min reminder, 6 hr reminder, and no-reminder). The three groups showed equivalent fear acquisition and extinction. Spontaneous recovery (first trial of re-extinction versus the last trial of extinction) was found in the group that had not been reminded or that was reminded 6 hours prior to extinction. In contrast, there was no spontaneous recovery in the group reminded 10 min before extinction. *Significant difference between acquisition and extinction, or extinction and re-extinction within group at p < 0.05; Error bars represent standard errors