Table 1.

Morphometric analysis of the ulnar nerve in cats affected with Niemann-Pick Disease compared to control cats

	Normal (n=6)	Affected (n=8)	P Value
MF Density	10826±1140 (8721–11980)	13007±4876 (7211–22200)	ns
Split MF Density	40±31 (5–80)	78±61 (13–79)	ns
% Split MF	0.4±0.3 (0.0–0.8)	0.6±0.4 (0.1–1.2)	ns
Thin MF Density	871±291 (297–1360)	1162±721 (467–2564)	ns
% Thin MF	7.8±3.1 (3.4–11.7)	8.4±2.6 (6.2–12.4)	ns
Cluster Density	1±1 (0–2)	27±27 (0–70)	0.03
# Myelinated Sprouts/Cluster	1±1 (0–3)	2±1 (0–3)	ns
Fiber diameter (μm)	8.82±1.53 (7.27–11.73)	6.91±0.82 (6.20–8.76)	0.03
Axonal diameter (μm)	5.40±0.86 (4.43–6.90)	4.38±0.60 (3.08–5.58)	0.04
G ratio	0.61±0.02 (0.59–0.65)	0.63±0.03 (0.59–0.68)	ns
Myelin thickness (μm)	1.73±0.35 (1.42–2.42)	1.26±0.17 (1.04–1.59)	0.02

Data are presented as mean±/SD (range) and were analyzed by a two-tailed, unpaired t-test. When variances were unequal, a t-test with Welch's correction was used. MF= myelinated fiber; split MF=fibers with split myelin sheaths including ballooned myelin sheaths; thin MF=fiber with myelin sheaths that are thin by comparison with those fibers with similar axonal diameter; G ratio=structural index of axonal myelination defined as axonal diameter/fiber diameter based on measurements by perimeter; ns-not significant