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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Cell Metab. 2009 Apr;9(4):311–326. doi: 10.1016/j.cmet.2009.02.002

Figure 4. BCAA supplementation of HF diet causes accumulation of acylcarnitines in skeletal muscle and chronic activation of mTOR and JNK.

Figure 4

A) Skeletal muscle samples were collected from animals fed on the indicated diets and used for acylcarnitine analysis by MS/MS. Data represent the mean ± SEM for 6 animals per group. (*) p < 0.05 for comparison of SC and SC/BCAA to HF and HF/BCAA groups. B) Representative p-mTOR2448, immunoblot in muscle from overnight fasted SC, SC/BCAA, HF, HF/AA, and HF/BCAA-fed rats; C) Quantitative summary of p-mTOR2448 analyses; D) Representative p-cJUNser63 immunoblot in muscle from the same sets of animals studied in panel B; E) Quantitative summary of p-cJUN analyses. (*) p < 0.05 for comparison of HF/BCAA to the other groups. (#) p<0.05 for comparison of SC and SC/BCAA to the other groups. In panels C and E, n = 6-9 animals/group.