Table 3.
Performance Characteristics of Biomarkers of Interstitial Inflammation for all the Biopsies1
| Biomarker | Threshold Value2 | Misclassifications (%) | Sens(%) | Spec(%) | PPV(%) | NPV(%) | AUC Under ROC |
|---|---|---|---|---|---|---|---|
| uMCP-1 | 2.2 | 10/64 (16) | 83 | 85 | 67 | 93 | 0.87 |
| uLFABP | 118 | 14/64 (22) | 65 | 83 | 58 | 87 | 0.75 |
| uHepcidin | 136.5 | 22/64 (34) | 83 | 60 | 42 | 90 | 0.70 |
| uPCR | 3.7 | 18/61 (30) | 56 | 76 | 45 | 83 | 0.65 |
| Scr | 1.43 | 13/64(20) | 83 | 79 | 58 | 93 | 0.86 |
| Eq (1) Y1 (applied to all biopsies) | 1 | 9/64 (14) | 100 | 81 | 67 | 100 | 0.92 |
| Eq (1) Y1 (applied to 49 biopsies) | 1 | 6/49 (12) | 100 | 83 | 68 | 100 | 0.91 |
1
Thresholds and models developed from the 49 cases taken at biopsy, and excluded repeat biopsies. Thresholds were chosen to maximize the observed sum of sensitivity and specificity for the associated biomarker.
2
With this value or greater classify as moderate-severe interstitial inflammation.