Table 4.
Performance Characteristics of Biomarkers of Interstitial Fibrosis for all the Biopsies1
| Biomarker | Threshold Value2 | Misclassifications (%) | Sens(%) | Spec(%) | PPV(%) | NPV(%) | AUC Under ROC |
|---|---|---|---|---|---|---|---|
| uMCP-1 | 1.51 | 25/63(40) | 65 | 59 | 37 | 80 | 0.66 |
| uLFABP | 148 | 17/63(27) | 41 | 85 | 50 | 80 | 0.60 |
| uHepcidin | 32.5 | 14/63(22) | 35 | 93 | 67 | 80 | 0.48 |
| uPCR | 4.0 | 13/60(22) | 67 | 80 | 56 | 88 | 0.72 |
| Scr | 0.81 | 26/63(41) | 94 | 46 | 39 | 95 | 0.75 |
| Eq (2) Y2 (applied to all biopsies) | −1 | 13/60(22)3 | 53 | 87 | 57 | 85 | 0.74 |
| Eq (2) Y2 (applied to 46 biopsies) | −1 | 8/46(17) | 64 | 89 | 64 | 88 | 0.76 |
1
Thresholds and models developed from the 46 cases taken at biopsy, and excluded repeat biopsies. Thresholds were chosen to maximize the observed sum of sensitivity and specificity for the associated biomarker Note that in this set there are 46 cases instead of 49 as for Table 3 because 3 cases were missing uPCR.
2
With this value or greater classify as moderate-severe interstitial fibrosis.
3
There are 60 biopsies here instead of 64 as in Table 3 because of missing uPCR in 4 cases.