Table 1.
Characteristics of 22 studies that evaluated HPV-16 and/or 18 in dysplastic oral or oropharyngeal lesions.
| Study | Year | Country | Number of samples (HPV positive/all dysplastic samples) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HPV-16/18b |
HPV-16 alone |
HPV-18 alone |
|||||||||
| ISH | SB/FB | PCR | ISH | SB/FB | PCR | ISH | SB/FB | PCR | |||
| Maitland et al.21 | 1987 | UK | – | 1/2 | – | – | – | – | – | – | – |
| Syrjanen et al.22 | 1988 | Finland | 3/21 | – | – | 2/21 | – | – | 1/21 | – | – |
| Greer et al.24 | 1990 | USA | 2/60 | – | – | 2/60 | – | – | 0/60 | – | – |
| Zeuss et al.27 | 1991 | USA | 0/15 | – | – | – | – | – | – | – | – |
| Young et al.28 | 1991 | USA | 0/3 | – | – | – | – | – | – | – | – |
| Shroyer et al.29 | 1991 | USA | 3/24 | 4/24 | – | – | 4/24 | – | – | – | |
| Holladay et al.30 | 1993 | USA | – | – | 6/27 | – | – | 6/27 | – | – | 0/27 |
| Cox et al.31 | 1993 | UK | – | 1/1 | – | – | 1/1 | – | – | – | – |
| Palefsky et al.33 | 1994 | USA | – | – | 9/13 | – | – | 9/13 | – | – | 1/13 |
| Fouret et al.34 | 1995 | France | – | – | 0/7 | – | – | 0/7 | – | – | 0/7 |
| Mao et al.35 | 1996 | USA | – | – | 2/5 | – | – | 2/5 | – | – | – |
| Fornatora et al.36 | 1996 | USA | 16/48 | – | – | – | – | – | – | – | – |
| Lo Muzio et al.40 | 1997 | Italy | 8/21 | – | – | – | – | – | – | – | – |
| Elamin et al.41 | 1998 | UK | – | – | 2/7 | – | – | 2/7 | – | – | – |
| Bouda et al.43 | 2000 | Greece | – | – | 5/5 | – | – | 3/5 | 4/5 | ||
| Ha et al.44 | 2002 | USA | – | – | 1/52 | – | – | 1/52 | – | – | – |
| Sugiyama et al.48 | 2003 | Japan | – | – | 31/51 | – | – | 31/51 | – | – | 0/51 |
| Begum et al.50 | 2005 | USA | 9/9 | – | – | 9/9 | – | – | – | – | – |
| Cunningham et al.53 | 2006 | USA | – | – | 5/41 | – | – | 5/41 | – | – | – |
| Bagan et al.54 | 2007 | Spain | – | – | 0/2 | – | – | 0/2 | 0/2 | ||
| Acay et al.56 | 2008 | Brazil | 4/30 | – | – | – | – | – | – | – | – |
| Angiero et al.60 | 2010 | Italy | – | – | 2/14a | – | – | – | – | – | – |
Abbreviations: ISH, in situ hybridization; SB/FB, Southern Blot / Filter blot; PCR, polymerase chain reaction.
a
Only moderate and severe dysplasia included.
b
HPV-16 alone or HPV-18 alone or both HPV-16/18.