Table 3.
Odds of HPV-16/18 detection in oral cavity and oropharyngeal lesions, stratified by histologic grade.
| Characteristic | Number of studies | Number of samples | Crude prevalence (%) | Adjusted odds ratiob | p-Value for trend |
|---|---|---|---|---|---|
| Type of lesion | 10 | ||||
| Benigna | 207 | 14.0 | 1 | ||
| Squamous dysplasia | 204 | 30.4 | 3.29 (1.95–5.53) | <0.001 | |
| OOSCC | 241 | 30.7 | 3.43 (2.07–5.69) | ||
| Grade of dysplasia | 8 | ||||
| Mild dysplasia | 67 | 28.4 | 1 | ||
| Moderate dysplasia | 73 | 28.8 | 1.05 (0.50–2.23) | 0.92 | |
| Severe dysplasia | 50 | 26.0 | 0.95 (0.41–2.20) |
a
Includes normal and simple keratotic lesions.
b
Adjusted by study ID and type of diagnostic test.