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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Virology. 2008 Aug 1;377(2):239–247. doi: 10.1016/j.virol.2008.04.031

Figure 1. Disease status in SIV infected animals.

Figure 1

CD4 absolute count (right panels) and plasma SIV RNA detected by branched DNA (left panels) from groups A-SIVmacJ5, B-SIVmacC8, and C- Mock infected macaques. Animals infected with SIVmacJ5 or SIVmacC8 show slow progressor patterns. Following challenge at week 20 with SHIV89.6P, two SIVmacC8 infected macaques show a rebound in viral load and a progressive drop in CD4 counts. SIV viral load target probes, designed to hybridize with the pol region of the SIVmac groups of strains were used to quantify SIV viral load. Results were quantified by comparison with purified and quantified in vitro-transcribed SIV pol RNA and were plotted on a log(10) scale. The detection limit of this assay was 1500 copies of SIVmac RNA per ml until week 35 and 500 thereafter. White blood cell counts were obtained from a hematology workstation and were used to calculate the absolute CD4 counts.