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Published in final edited form as: Virology. 2008 Aug 1;377(2):239–247. doi: 10.1016/j.virol.2008.04.031

Longitudinal analysis of the CD4 TCR repertoire prior to, following SIV and SHIV89.6P challenge at week 20. Vertical lines delineates between pre-challenge and post-challenge time points. A- Animals resistant to SHIV89.6P super-infection (refer also to figure 4A for animal C94066F, TRBV5-1). B- Animals susceptible to SHIV89.6P super-infection. C-Mock infected animals infected with SHIV89.6P at week 20. Whereas animals susceptible to SHIV89.6P super-infected have a highly diverse repertoire pre and post challenge, macaques resistant to super-infection have restricted repertoire post challenge, and some are composed of dominant CD4 clonotypes that have been generated pre-challenge during acute SIV infection.

Longitudinal analysis of the CD4 TCR repertoire prior to, following SIV and SHIV89.6P challenge at week 20. Vertical lines delineates between pre-challenge and post-challenge time points. A- Animals resistant to SHIV89.6P super-infection (refer also to figure 4A for animal C94066F, TRBV5-1). B- Animals susceptible to SHIV89.6P super-infection. C-Mock infected animals infected with SHIV89.6P at week 20. Whereas animals susceptible to SHIV89.6P super-infected have a highly diverse repertoire pre and post challenge, macaques resistant to super-infection have restricted repertoire post challenge, and some are composed of dominant CD4 clonotypes that have been generated pre-challenge during acute SIV infection.