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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Pharm Res. 2013 Feb 16;30(4):932–950. doi: 10.1007/s11095-012-0912-4

Scheme 1.

Scheme 1

General procedure for synthesis of antiprion 2-AMTs. Conditions: (a) BzNCS, acetone, reflux; (b) NaOH, MeOH, reflux; (c) EtOH, reflux.