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AUC values for brain (black) and plasma (white) and AUC/EC50 ratios for brain (vertical stripes) and plasma (horizontal stripes) based on brain and plasma concentrations for ten AMTanalogs and Compd B. Values are based on a dose of 210 and 100 mg/kg/day given for 3 days for the AMTanalogs and Compd B, respectively. AUC values calculated from C3-day × τ, as described in the Methods.
