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AUC values for brain (black) and plasma (white) and AUC/EC50 ratios for brain (vertical stripes) and plasma (horizontal stripes) based on brain and plasma concentrations and corrected for fraction unbound for IND81, IND24, and Compd B. Values are based on a dose of 210 mg/kg/day (IND81 and IND24) or 100 mg/kg/day (Compd B) given for 3 days. AUC values calculated from C3-day × τ, as described in Methods.
