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Metabolic Stability of 9 Selected 2-AMT Compounds and Compd B
| Compound | t1/2 in min (% remaining after a 60-min incubation)
|
||
|---|---|---|---|
| Mouse | Rat | Human | |
| IND22 | 49 (40) | >60 (64) | >60 (99) |
| IND24 | >60 (89) | >60 (90) | >60 (105) |
| IND33 | >60 (111) | >60 (73) | 54 (42) |
| IND44 | 29 (24) | 45 (39) | 58 (48) |
| IND46 | >60 (58) | >60 (61) | >60 (83) |
| IND47 | >60 (56) | >60 (50) | >60 (113) |
| IND52 | 6 (0) | 16 (8) | 36 (30) |
| IND81 | 19 (10) | 58 (48) | 52 (48) |
| IND85 | 15 (6) | 18 (32) | 53 (66) |
| Compd B | 30 (29) | >60 (77) | >60 (68) |
