Table IV.
Compound | Sample | Unbound (%) |
---|---|---|
IND24 | Mouse Plasma | 6.63±1.55 |
Mouse Brain Homogenate | 8.20±0.35 | |
Human Plasma | 4.91±1.03 | |
Cell-culture Media | 25.7±4.93 | |
IND81 | Mouse Plasma | 6.48±1.10 |
Mouse Brain Homogenate | 9.43±1.49 | |
Human Plasma | 5.78±3.21 | |
Cell-culture Media | 23.2±2.68 | |
Compd B | Mouse Plasma | 9.06±2.31 |
Mouse Brain Homogenate | 11.4±2.89 | |
Human Plasma | 2.10±1.11 | |
Cell-culture Media | 36.5±3.30 | |
Warfarin | Mouse Plasma | 10.8±0.0044 |
Human Plasma | 0.68±0.0023 |