Table IV.

Fraction Unbound of IND24, IND81, and Compd B in Mouse Brain Homogenate, Mouse and Human Plasma, and Cell-Culture Media at 1 μM. Mean Percentage ± SD Based on n=3, Except For Warfarin Where n=2

Compound	Sample	Unbound (%)
IND24	Mouse Plasma	6.63±1.55
	Mouse Brain Homogenate	8.20±0.35
	Human Plasma	4.91±1.03
	Cell-culture Media	25.7±4.93
IND81	Mouse Plasma	6.48±1.10
	Mouse Brain Homogenate	9.43±1.49
	Human Plasma	5.78±3.21
	Cell-culture Media	23.2±2.68
Compd B	Mouse Plasma	9.06±2.31
	Mouse Brain Homogenate	11.4±2.89
	Human Plasma	2.10±1.11
	Cell-culture Media	36.5±3.30
Warfarin	Mouse Plasma	10.8±0.0044
	Human Plasma	0.68±0.0023