Skip to main content
. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Pharm Res. 2013 Feb 16;30(4):932–950. doi: 10.1007/s11095-012-0912-4

Table V.

Observed (Obs.) and Calculated (Calc.) Molecular Ions And Mass Spectral Fragment Ions of IND24 and its Metabolites (top panel), and IND81 and its Metabolites (bottom panel) Following Incubation With Human, Mouse, Rat, and Dog Liver Microsomes

Metabolite Structure Molecular Ions Fragment Ions
MH+ a b c d e
Parent IND24 graphic file with name nihms446883t29.jpg Obs. 344.1212 226.0687 209.0421 193.0887 165.0698
Calc. 344.1216 226.0684 209.0420 193.0886 165.0687
M1 graphic file with name nihms446883t30.jpg Obs. 360.1162 342.1060 35.0951 309.1262 161.0167
Calc. 360.1165 342.1059 315. 0950 309.1260 6.0167
M2/M3/M4 graphic file with name nihms446883t31.jpg Obs. 360.1158 242.0634 225.0369 209.0835 181.0647
Calc. 360.1165 242.0634 225.0363 209.0835 181.0647
M5 graphic file with name nihms446883t32.jpg Obs. 360.1160 226.0686 209.0421 193.0886 65.0698
Calc. 360.1165 226.0684 209.0420 193.0886 165.0687
Parent IND8 graphic file with name nihms446883t33.jpg Obs. 351.0729 243.0048 233.0205 218.0096 206.0095
Calc. 351.0732 243.0039 233.0202 218.0092 206.0092
M1/M3 graphic file with name nihms446883t34.jpg Obs. 367.0680 258.9997 249.0154 234.0045 222.0045
Calc. 367.0681 258.9988 249.0150 234.0042 222.0041
M2 graphic file with name nihms446883t35.jpg Obs. 367.0679 243.0048 233.0204 218.0095 206.0094 349.0576
Calc. 351.0732 243.0039 233.0202 218.0092 206.0092 349.0579