Table 3.
Kinetic parameters for ATP in wild-type MRP2 and variants S789F and A1450T
Kinetic parameters | WT | S789F | A1450T |
---|---|---|---|
Km | 79 (43–114) |
125 (96–155) |
101 (57–146) |
Vmax | 2630 (2433–2927) |
1796 (1721–1870)* |
2242 (2071–2413)* |
Nonlinear regression results [Km, (µM); Vmax (pmol·mg−1·min−1)] were obtained from data in Figure 3B. Values in brackets are the 95% Confidence Limits.
Significantly different from WT, as determined by non- overlapping 95% Confidence Limits.