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. Author manuscript; available in PMC: 2013 Dec 7.
Published in final edited form as: J Proteome Res. 2012 Oct 30;11(12):5592–5601. doi: 10.1021/pr300796m

Figure 1. Creating a reference review profile to calibrate diagnoses from pathologists.

Figure 1

Top panel. All pathologists enrolled to read study specimens will review the same set of digital images of a reference set, selected to represent a broad range of relevant histopathologies, including ambiguous cases. A reference review profile that indicates how each pathologist scored each reference specimen will then be stored in a database. Bottom panel. When new specimens arrive they are assigned to be read by individual pathologists. The resulting diagnoses will be evaluated in the context of the pathologist’s reference profile and both the original diagnosis and an adjusted diagnosis will be reported. The adjusted diagnosis may help in interpreting diagnoses by highlighting samples where pathologists may disagree. Obviously, a very similar approach could be taken with radiologists and other professionals who render opinions on data to make diagnoses.