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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Fertil Steril. 2005 Sep;84(3):701–710. doi: 10.1016/j.fertnstert.2005.02.045

TABLE 2.

Reference intervals: steroid function tests in pregnancy.

Reference intervals
Analyte n Meana (±SE) Median 2.5th percentile 97.5th percentile
E2 (ng/mL, pmol/L)b
  First trimesterc 51 0.87 ± 0.07, 3,211.2 ± 253.2 0.87, 3,211.2 0.31, 1,137.8 3.00, 11,010
  Second trimester 50 4.24 ± 0.26, 15,546.1 ± 961.5 4.29, 15,744.3 1.91, 7,009.7 10.33, 37,911.11
  Third trimester 50 6.18 ± 0.41, 22,680.6 ± 1493.7 6.56, 24,075.2 2.17, 7,963.9 13.85, 50,829.5
  Postpartum 50 <0.1 ± 0.015, <367.0 ± 55.0 <0.1, <367 — 1.24, 4,550.8
P (ng/mL, nmol/L)
  First trimester 51 17.48 ± 0.87, 55.87 ± 2.78 18.60, 59.15 7.41, 23.56 35.16, 111.80
  Second trimester 50 42.30 ± 2.33, 134.51 ± 7.4 43.30, 137.69 15.78, 50.18 76.84, 244.35
  Third trimester 50 70.45 ± 3.32, 224.03 ± 10.56 72.90, 231.82 34.86, 110.85 138.40, 440.11
  Postpartum 50 0.86 ± 0.20, 2.73 ± 0.62 0.69, 2.19 <0.1, <0.32 22.92, 72.88
17α-hydroxyprogesterone (ng/mL, nmol/L)
  First trimester 51 1.34 ± 0.09, 4.02 ± 0.27 1.36, 4.08 0.48, 1.44 3.77, 11.31
  Second trimester 50 2.30 ± 0.12, 6.90 ± 0.35 2.30, 6.9 1.13, 3.39 4.67, 14.01
  Third trimester 50 3.51 ± 0.18, 10.53 ± 0.55 3.50, 10.5 1.53, 4.59 7.00, 21.00
  Postpartum 50 0.40 ± 0.06, 1.19 ± 0.19 0.41, 1.23 <0.1, <0.3 4.95, 14.85
Cortisol (ng/mL, nmol/L)
  First trimester 51 139.84 ± 9.16, 385.95 ± 25.28 143.00, 394.68 48.28, 133.25 385.10, 1065.88
  Second trimester 50 286.21 ± 13.94, 789.94 ± 38.47 290.50, 801.78 156.65, 432.35 605.22, 1670.41
  Third trimester 50 286.79 ± 13.03, 791.54 ± 35.96 305.50, 843.18 114.30, 315.47 477.37, 1,317.54
  Postpartum 50 107.38 ± 6.73, 296.37 ± 18.57 97.60, 269.38 35.56, 98.15 293.05, 808.82
11-Deoxycortisol (ng/mL, nmol/L)
  First trimester 50 0.63 ± 0.06, 1.83 ± 0.19 0.67, 1.94 0.13, 0.38 2.45, 7.10
  Second trimester 50 1.69 ± 0.11, 4.89 ± 0.31 1.67, 4.84 0.71, 2.06 5.66, 16.41
  Third trimester 50 1.94 ± 0.13, 5.63 ± 0.38 2.05, 5.94 0.70, 2.03 4.06, 11.77
  Postpartum 49 0.35 ± 0.04, 1.02 ± 0.13 0.38, 1.10 <0.1, <0.29 1.46, 4.23
DHEA (ng/mL, nmol/L)
  First trimester 51 1.93 ± 0.15, 6.71 ± 0.53 1.89, 6.56 0.57, 1.98 6.82, 23.67
  Second trimester 50 1.88 ± 0.28, 6.54 ± 0.96 1.84, 6.38 0.15, 0.52 10.18, 35.32
  Third trimester 50 2.11 ± 0.29, 7.32 ± 1.01 1.70, 5.89 0.24, 0.83 15.02, 52.12
  Postpartum 50 1.92 ± 0.25, 6.66 ± 0.86 1.92, 6.66 <0.1, <0.35 5.74, 19.92
Androstenedione (ng/mL, nmol/L)
  First trimester 51 0.77 ± 0.06, 2.68 ± 0.22 0.74, 2.58 0.17, 0.59 2.72, 9.49
  Second trimester 50 0.75 ± 0.07, 2.63 ± 0.23 0.75, 2.62 0.10, 0.35 2.48, 8.65
  Third trimester 50 0.76 ± 0.08, 2.65 ± 0.26 0.75, 2.62 0.08, 0.28 2.81, 9.81
  Postpartum 50 0.42 ± 0.04, 1.46 ± 0.14 0.39, 1.36 <0.1, <0.35 1.27, 4.45
DHEAS (ng/mL, nmol/L)
  First trimester 51 568.29 ± 63.29, 1.53 ± 0.17 598.00, 1.61 100.14, 2.70 2,501.00, 67.53
  Second trimester 50 388.06 ± 43.68, 1.05 ± 0.12 413.50, 1.12 72.57, 1.96 1,443.25, 38.97
  Third trimester 50 294.82 ± 35.26, 0.80 ± 0.09 313.50, 0.85 54.65, 1.47 1,092.05, 29.48
  Postpartum 50 596.12 ± 62.24, 1.61 ± 0.17 647.00, 1.75 129.10, 3.48 2,898.75, 78.27
a

All values are geometric means ± SE.

b

Conversion factors from ng/mL to SI units: E2 ng/mL × 3,670 = pg/mL; P4 × 3.18 = nmol/L; 17OHP × 3 = nmol/L; cortisol × 2.76 = nmol/L; cor-11D × 2.9 = nmol/L; DHEA × 3.47 = nmol/L; androstenedione × 3.49 = nmol/L; DHEAS × 0.0027 = nmol/L.

c

First trimester = week 12; second trimester = week 22; third trimester = week 32.