Figure 5.
Effect of asperolide A on tumor growth in a xenograft model. (A) BALB/c male athymic mice were injected 5 × 106 NCI-H460 cells s.c. for the development of subcutaneous tumors. The mice were randomized into 3 groups (N = 9) and treated with Vehicle (1% DMSO), 2.5 mg/kg Cisplatin or 5 mg/kg asperolide A i.v. according to the protocol in panel (A); (B) Tumor image from various treatment groups; (C) Average tumor mass at sacrifice. ## p < 0.001; (D) Tumor volume measurements; (E) Body weight of mice from control, Cisplatin and asperolide A treated groups.