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. 2013 Jan 30;11(2):332–349. doi: 10.3390/md11020332

Figure 5.

Figure 5

Iodinin exhibit low toxicity towards normal cells and tissues. (A) Rat cardiomyoblasts (H9C2) were incubated with iodinin or DNR for 24 h before viability was assessed by microscopic evaluation of surface morphology. (B) Peripheral blood leukocytes were incubated with the indicated concentrations of iodinin or DNR for 24 h before FACS analysis of AnnexinV and PI staining. (C) Blood platelets were incubated (15 min) with increasing concentrations of the thrombin receptor agonist peptide (TRAP) with or without iodinin or DNR and activation was determined as described in the Experimental section. Platelets incubated with 20 μM TRAP was set as 100% activation. The data are average of three to five experiments and SEM (A) and (C), or two experiments and each measurement (B). Asterisks denote significance at p < 0.05 (*), <0.01 (**), <0.005 (***), t-test in (A–C). (D and E) Histological appearance of duodenum of mice given vehicle, (D) or iodinin (10mg/kg, E) daily for three days. Organs were collected the day after the last treatment. See Experimental Section for further details.