Table 2.

AML patient characteristics. APL and AML blasts were isolated from 6 patients. Patient age and sex are listed, together with FAB classification, cytogenetic findings, and Flt3 and NPM1 mutation state of their isolated blasts. ITD = internal tandem duplication, ins = insertion, nd = not determined. Patient AML#1 and AML#6 reached complete haematological remission after two induction cycles (cytarabine in combination with an anthracycline), whereas patients AML#3 and AML#5 reached complete remission after the first induction cycle. AML#4 relapsed 11 months after first remission and was given 22 rounds of intensive chemotherapy (cytarabine), but second remission was not reached. Blasts from patient AML#4 were obtained after diagnosis of relapse. APL#2 was treated according to the regimen described by Fenaux et al. [1], and reached haematological remission after the induction cycle, and was in molecular remission after the second consolidation cycle before start of maintenance therapy.

Patients	Age	Sex	Cytogenetics	FABclassification	FLt3	NPM1
AML#1	24	M	Multiple	M2	wt	wt
APL#2	39	M	T(15;17)	M3	wt	wt
AML#3	48	M	Inv(16)	M4	wt	wt
AML#4	29	M	Normal	M4	ITD	Ins
AML#5	18	F	Inv(16)	M4	wt	wt
AML#6	29	F	Normal	M5	wt	nd