Table 3.
Effects of HPN on serum lipid in db/db mice.
| Group | Dose (mg/kg) | Triglycerides (mmol/L) a | Total cholesterol (mmol/L) a | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 4 weeks | 8 weeks | Baseline | 4 weeks | 8 weeks | |||
| Control | 1.19 ± 0.25 | 1.30 ± 0.26 | 1.19 ± 0.24 | 3.01 ± 0.83 | 3.32 ± 0.80 | 2.99 ± 0.72 | ||
| Model | 1.47 ± 0.30 * | 1.69 ± 0.39 * | 1.74 ± 0.40 ** | 4.20 ± 1.17 * | 7.22 ± 2.91 ** | 7.18 ± 2.18 ** | ||
| HPN | 40 | 1.36 ± 0.35 | 1.32 ± 0.21 # | 1.32 ± 0.34 # | 3.89 ± 0.93 | 4.67 ± 1.55 # | 5.01 ± 1.64 # | |
| 20 | 1.44 ± 0.42 | 1.32 ± 0.27 # | 1.36 ± 0.31 # | 3.86 ± 1.42 | 5.01 ± 1.45 | 5.12 ± 2.31 | ||
| 10 | 1.44 ± 0.28 | 1.45 ± 0.30 | 1.47 ± 0.32 | 4.72 ± 0.91 | 5.54 ± 1.59 | 5.79 ± 1.69 | ||
| Rosiglitazone | 20 | 1.46 ± 0.23 | 1.33 ± 0.27 # | 1.36 ± 0.23 # | 4.19 ± 1.04 | 4.67 ± 1.42 # | 4.44 ± 1.60 ## | |
a Data are expressed as means ± SD, n = 10; # P < 0.05, ## P < 0.01 when compared to the model group; ** P < 0.01 when compared to the control group.