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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Breast Cancer Res Treat. 2011 Oct 15;131(3):1003–1012. doi: 10.1007/s10549-011-1789-3

Figure 1. Differential Gene Expression by Obesity Status.

Figure 1

A genomic signature (760 genes) differentially expressed between normal breast tissue of obese (BMI ≥ 30 kg/m2) and normal-weight (BMI< 25 kg/m2) reduction mammoplasty patients (FDR<0.026). (A) One-way (genes only) clustering of the identified signature (203 up and 557 down) with 74 patients ordered by BMI. (B) Two-way clustering (genes and samples) of the identified signature. Three clusters were identified with one enriched for obese patients (left), one enriched for normal-weight patients (middle). (C) The percentage of patients in obese-enriched cluster based on two-way cluster analysis increased with BMI. The number above each bar was the count of patient in each category.