Table 2.

Functional analysis of the differentially expressed signature by obesity status based on the Ingenuity Pathways Analysis (IPA).

Up-regulated
Diseases and Disorders	p-value
Endocrine System Disorders	2.60E-04 - 2.90E-02
Genetic Disorde	2.60E-04 - 4.19E-02
Metabolic Disease	2.60E-04 - 3.55E-02
Reproductive System Disease	1.55E-03 - 3.93E-02
Hematological Disease	2.87E-03 - 4.19E-02
Top Canonical Pathways	p-value
IL-6 Signaling	1.8E-02
PPARα/RXRα Activation	2.63E-02
Phospholipase C Signaling	3.45E-02
IL-8 Signaling	3.6E-02
CCR5 Signaling in Macrophages	3.72E-02
Down-regulated
Diseases and Disorders	p-value
Dermatological Disease and Conditions	2.23E-04 - 4.51E-02
Connective Tissue Disorders	6.37E-04 - 4.51E-02
Genetic Disorder	6.37E-04 - 4.81E-02
Cancer	7.29E-04 - 4.81E-02
Infection Mechanism	7.29E-04 - 9.76E-03
Top Canonical Pathways	p-value
MSP-RON Signaling Pathway	1.87E-04
Wnt/β-catenin Signaling	7.25E-04
Cardiac β-adrenergic Signaling	8.34E-03
Agrin Interactions at Neuromuscular Junction	9.35E-03
Virus Entry via Endocytic Pathways	1.03E-02